Automation of sample processing for dicentric analysis can increase throughput with customization of off-the-shelf technologies for cytogenetic sample processing and information management. Analysis of dicentrics, a marker specific for radiation injury, is the “Gold standard†of biodosimetry and can reveal partial-body exposures. Use of a combination of markers and symptoms will be needed for clinical insights for therapeutic approaches. Organ specific biomarkers may provide early warning regarding physiological systems at risk after radiation injury. Clinical signs and symptoms, distribution of dicentrics in circulating blood cells, organ-specific biomarkers, physical signals in teeth and nails all can provide indications of non-homogeneous exposures. Partial-body biodosimetry is likely to be required after a radiological or nuclear exposure. TRIAGE DOSE ASSESSMENT FOR PARTIAL-BODY EXPOSURE: DICENTRIC ANALYSIS
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